PROTECTION AGAINST TABUN TOXICITY IN MICE BY PROPHYLAXIS WITH AN ENZYME HYDROLYZING ORGANOPHOSPHATE ESTERS

被引：41

作者：

RAVEH, L

SEGALL, Y

LEADER, H

ROTHSCHILD, N

LEVANON, D

HENIS, Y

ASHANI, Y

机构：

[1] ISRAEL INST BIOL RES,POB 19,IL-70450 NESS ZIONA,ISRAEL

[2] HEBREW UNIV JERUSALEM,FAC AGR,IL-76100 REHOVOT,ISRAEL

[3] MIGAL GALILEE TECHNOL CTR,KIRYAT SHMONA,ISRAEL

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 02期

关键词：

D O I：

10.1016/0006-2952(92)90028-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We demonstrate here the correlation between protection afforded by pretreatment alone with parathion hydrolase purified from Pseudomonas sp. against tabun toxicity in mice and the kinetic parameters which are assumed to determine the in vivo detoxification of tabun by the same enzyme. Results show that 15 and 22-mu-g of parathion hydrolase per animal conferred a protective ratio of 3.94 and 5.65 respectively, against tabun toxicity, without post-exposure treatment.

引用

页码：397 / 400

页数：4

共 10 条

[1] PROPHYLAXIS AGAINST ORGANOPHOSPHATE POISONING BY AN ENZYME HYDROLYZING ORGANOPHOSPHORUS COMPOUNDS IN MICE [J].