DEVELOPMENT OF AN INVITRO MICROTEST TO ASSESS DRUG SUSCEPTIBILITY OF BABESIA-BOVIS AND BABESIA-BIGEMINA

被引：14

作者：

BROCKELMAN, CR

TANARIYA, P

机构：

来源：

JOURNAL OF PARASITOLOGY | 1991年 / 77卷 / 06期

关键词：

D O I：

10.2307/3282755

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Continuous cultivation of the bovine hemoparasites Babesia bovis and Babesia bigemina was developed as an in vitro microtest to assess parasite susceptibility to babesicidal compounds. Reproducibility of parasite multiplication rates was independent of culture size, making it possible to use a microscale of 100-mu-l for each test sample. Inhibitory concentrations (IC50s) of a commonly used babesicide, quinuronium sulfate, evaluated by this in vitro method were found to be 5 x 10(-8) g/ml for B. bovis and 2 x 10(-9) g/ml for B. bigemina.

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页码：994 / 997

页数：4

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