ROLE OF SEROTONIN AND CATECHOLAMINES IN BRAIN IN THE FEEDING SUPPRESSANT EFFECT OF FLUOXETINE

被引:31
作者
GRIGNASCHI, G [1 ]
SAMANIN, R [1 ]
机构
[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY
关键词
SEROTONIN RECEPTORS; ANOREXIA; FLUOXETINE;
D O I
10.1016/0028-3908(92)90082-Z
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The hypophagic effect of fluoxetine was studied in rats, injected intracerebroventricularly with 150-mu-g/20-mu-l 5,7-dihydroxytryptamine, to destroy serotonin-containing neurones or 250-mu-g/20-mu-l 6-hydroxydopamine, to destroy catecholamine-containing neurones. The effect of various serotonin receptor antagonists was assessed as well. Neither neurotoxin significantly modified the effect of 20 mg/kg (i.p.) fluoxetine on food intake. Metergoline (1-5 mg/kg), ( - )-propranolol (16 mg/kg) and ICS 205-930 (0.1 and 1 mg/kg) did not modify the hypophagic effect of fluoxetine, while mianserin (1 and 5 mg/kg), ritanserin (0.5 and 1 mg/kg) and xylamidine (3 mg/kg) slightly but significantly reduced it. While the mechanism by which some 5-HT receptor antagonists modify the effect of fluoxetine remains to be elucidated, it seems clear that 5-HT receptors hardly have any significant role in the ability of the drug to suppress food intake.
引用
收藏
页码:445 / 449
页数:5
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