DEVELOPMENT OF CONGENIC STRAINS OF MICE CARRYING AMYLOIDOGENIC APOLIPOPROTEIN A-II (APOA2(C)) - APOA2(C) REDUCES THE PLASMA-LEVEL AND THE SIZE OF HIGH-DENSITY-LIPOPROTEIN

被引：29

作者：

HIGUCHI, K ^{[1
]}

KITADO, H ^{[1
]}

KITAGAWA, K ^{[1
]}

KOGISHI, K ^{[1
]}

NAIKI, H ^{[1
]}

TAKEDA, T ^{[1
]}

机构：

[1] FUKUI MED SCH,DEPT PATHOL,FUKUI 91011,JAPAN

来源：

FEBS LETTERS | 1993年 / 317卷 / 03期

关键词：

AMYLOIDOGENIC APOLIPOPROTEIN A-II; CONGENIC MOUSE; HIGH DENSITY LIPOPROTEIN; SENESCENCE ACCELERATED MOUSE (SAM);

D O I：

10.1016/0014-5793(93)81277-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A congenic strain of mice with amyloidogenic apolipoprotein A-II (Apoa2c) on the genetic background of the amyloidosis-resistant SAM-R/1 strain was produced by 12 generations of backcrossing. Genome mapping using endogenous murine leukemia proviral markers was done in the congenic strain, termed R1.P1-Apoa2c. We confirmed that only a small region surrounding the apoA-II gene on chromosome 1 was transferred from the genome of the donor SAM-P/1 strain. The level and particle size of plasma high density lipoprotein were decreased in R1.P1-Apoa2c mice compared to those in the progenitor SAM-R/1 mice. The function of apoA-II can be studied using this strain of mice.

引用

页码：207 / 210

页数：4

共 17 条

[1]

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