CYTOGENETIC EFFECT OF MALATHION IN INVITRO CULTURE OF HUMAN PERIPHERAL-BLOOD

被引：28

作者：

BALAJI, M ^{[1
]}

SASIKALA, K ^{[1
]}

机构：

[1] BHARATHIAR UNIV,DEPT ZOOL,DIV HUMAN GENET,COIMBATORE 641046,INDIA

来源：

MUTATION RESEARCH | 1993年 / 301卷 / 01期

关键词：

SISTER-CHROMATID EXCHANGE; MITOTIC INDEX; CHROMOSOMAL ABERRATIONS;

D O I：

10.1016/0165-7992(93)90050-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal aberrations, sister-chromatid exchanges and mitotic indices were observed in human peripheral leukocytes, treated with four different concentrations of malathion (0.02, 0.2, 2 and 20 mug/ml), an organophosphate pesticide, added to the culture medium at 0, 24 and 48 h after culture initiation. These cultures showed a dose-dependent increase in the frequency of chromosomal aberration as well as sister-chromatid exchanges. There was a significant decrease in mitotic index at all concentrations.

引用

页码：13 / 17

页数：5

共 17 条

[1] DOMINANT LETHAL STUDIES WITH PARAQUAT AND DIQUAT IN MALE CD-1 MICE
ANDERSON, D
MCGREGOR, DB
PURCHASE, IFH
[J]. MUTATION RESEARCH, 1976, 40 (04): : 349 - 358
[2] MUTAGENESIS BY CHEMICAL-AGENTS IN V79 CHINESE-HAMSTER CELLS - A REVIEW AND ANALYSIS OF THE LITERATURE - A REPORT OF THE GENE-TOX PROGRAM
BRADLEY, MO
BHUYAN, B
FRANCIS, MC
LANGENBACH, R
PETERSON, A
HUBERMAN, E
[J]. MUTATION RESEARCH, 1981, 87 (02): : 81 - 142
[3] INDUCTION OF SISTER-CHROMATID EXCHANGES AND CELL-CYCLE DELAY IN CULTURED MAMMALIAN-CELLS TREATED WITH 8 ORGANO-PHOSPHORUS PESTICIDES
CHEN, HH
HSUEH, JL
SIRIANNI, SR
HUANG, CC
[J]. MUTATION RESEARCH, 1981, 88 (03): : 307 - 316
[4] MUTAGENIC EFFECTS OF ORGANOPHOSPHORUS PESTICIDES ON MICROORGANISMS
DEAN, BJ
[J]. ARCHIV FUR TOXIKOLOGIE, 1972, 30 (01): : 67 - 74
[5] GABLIKS J, 1967, P SOC EXP BIOL MED, V125, P1002
[6] GIRI AK, 1981, PERSPECTIVES CYTOLOG, V3, P407
[7] HUANG C C, 1973, Proceedings of the Society for Experimental Biology and Medicine, V142, P36, DOI 10.3181/00379727-142-36952
[8] LEUKOCYTES CULTURED FROM SMALL INOCULA OF WHOLE BLOOD AND PREPARATION OF METAPHASE CHROMOSOMES BY TREATMENT WITH HYPOTONIC KCL
HUNGERFORD, DA
[J]. STAIN TECHNOLOGY, 1965, 40 (06): : 333 - +
[9] Manna G.K., 1986, PERS CYTOL GENET, V5, P225
[10] MCCANN JE, 1975, P NATL ACAD SCI USA, V72, P3162

← 1 2 →