Continuous accumulation of dust during the Quaternary has formed widespread loess deposits in southern Tajikistan. The magnetic susceptibility variations of these aeolian sediments have recorded the paleoclimatic fluctuations in a similar direct and complete way to the well-studied sediments from the central loess plateau in China [11]. Susceptibility measurements were carried out in situ at intervals of 10 cm along seven partly overlapping sections in the loess/paleosol sequence of Karamaidan (ca. 100 km east of Dushanbe). Nearly 250 oriented samples were taken for rock-magnetic investigations. Careful field observation revealed a total actual loess thickness of ca. 100 m for a composite profile with thirteen intervening pedocomplexes (PC). Standard demagnetization techniques yielded a characteristic component of natural remanent magnetization (NRM) which was used to obtain a well-defined magnetostratigraphy. The section covers a total timespan of approximately 1 m.y., including the Brunhes and the youngest part of the Matuyama polarity chron. The susceptibility variations correlate excellently with those of the Chinese loess record at Xifeng [22], although minor differences in the relative amplitude of the susceptibility signal occur. Close correlation with the astronomically tuned oxygen isotope record [26] enables refined dating of the loess sequence at Karamaidan and demonstrates the global significance of the recorded paleoclimatic variations, especially with respect to paleoprecipitation on land during the Quaternary.