DISTRIBUTION AND STEROID DEPENDENCE OF AROMATASE ENZYME IMMUNOREACTIVITY IN LIMBIC NUCLEI OF THE FEMALE MUSK SHREW BRAIN

被引:13
作者
DELLOVADE, TL
HARADA, N
RISSMAN, EF
机构
[1] UNIV VIRGINIA,DEPT BIOL,CHARLOTTESVILLE,VA 22903
[2] FUJITA GAKUEN HLTH UNIV,SCH MED,TOYOAKE,AICHI,JAPAN
基金
美国国家科学基金会;
关键词
AROMATASE ENZYME; MUSK SHREW; IMMUNOCYTOCHEMISTRY; SEXUAL BEHAVIOR; LIMBIC REGION; ESTROGEN RECEPTOR; SEPTUM; AMYGDALA;
D O I
10.1016/0006-8993(94)90267-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the female musk shrew (Suncus murinus) neural aromatization of testosterone to estradiol is critical for the expression of sexual behavior. To localize the brain regions capable of aromatization, we used immunocytochemistry to map the distribution of aromatase enzyme. Aromatase immunoreactivity (AROM-ir) has a discrete distribution primarily limited to the lateral septum (LS), central nuclei of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST). In these nuclei the intensity of immunoreactivity varies with hormonal status. Ovariectomy (OVX) significantly reduces the optical density of AROM-ir neurons in all nuclei as compared with brains of normal females. Combined OVX and adrenalectomy (ADX) further reduces optical density readings in AROM-ir cells in the LS and BST, as compared with readings from the brains of OVX animals. Normal and ovariectomized females implanted with testosterone had qualitatively equivalent AROM-ir. High levels of aromatase activity have been measured in the preoptic area and hypothalamus in a number of mammals, including the musk shrew. However, in this experiment AROM-ir was absent in these areas. We present several hypotheses to account for this discrepancy between previously reported biochemical data and these histological data. In summary, these data suggest that limbic nuclei may play a role in the expression of sexual behavior in female musk shrews.
引用
收藏
页码:141 / 149
页数:9
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