A STUDY OF INTERFERENCES IN ROUTINE METHODS FOR CREATININE MEASUREMENT

被引：9

作者：

KENNY, D

机构：

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1993年 / 53卷

关键词：

ACETOACETATE; BILIRUBIN; CREATININE; INTERFERENCE; JAFFE REACTION;

D O I：

10.3109/00365519309085455

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A survey was undertaken through the Irish External Quality Assessment Scheme to investigate the extent to which acetoacetate and bilirubin affect routine methods in current use for measurement of serum creatinine. Spiking a sample with 10 mmol/l acetoacetate caused errors ranging from -28 % to +22 %. The greatest errors were found with end-point Jaffe methods and kinetic Jaffe methods in which there was no time delay between final reagent addition and start of absorbance measurement. A sample with high bilirubin concentration gave apparent creatinine results ranging from zero to 280 mumol/l. Although these interferences are well documented in the literature, this knowledge seems to have had little effect on methods in actual use.

引用

页码：43 / 47

页数：5

共 4 条

[1]

BOWERS LD, 1980, CLIN CHEM, V26, P555

[2] A COMPARISON OF THE EFFECT OF ACETOACETATE CONCENTRATION ON THE MEASUREMENT OF SERUM CREATININE USING TECHNICON SMAC-II, BECKMAN ASTRA AND ENZYMATIC TECHNIQUES [J].