QUANTIFYING THE SOFT-TISSUE RESPONSE TO IMPLANTED MATERIALS

As the diversity of biomaterials increases, new developments are aimed at these materials becoming interactive rather than passive with respect to the environment they are placed in. The need accurately and reproducibly to assess the response of the body to these materials increases. Historically, quantification of tissue responses has taken many forms but with the continuing development of powerful computers, our ability to quantify the tissue response to implanted materials has become a reality. Computer systems can now analyse sections automatically and then go on to sort the huge quantities of data created, into in depth patterns and cross comparisons so that subtle changes in tissue responses can be detected and understood.