ULTRAVIOLET-B IRRADIATION INCREASES ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR EXPRESSION IN CULTURED HUMAN KERATINOCYTES

被引：35

作者：

TSUBOI, R ^{[1
]}

SATO, C ^{[1
]}

OSHITA, Y ^{[1
]}

HAMA, H ^{[1
]}

SAKURAI, T ^{[1
]}

GOTO, K ^{[1
]}

OGAWA, H ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN

来源：

FEBS LETTERS | 1995年 / 371卷 / 02期

关键词：

ENDOTHELIN-1; ENDOTHELIN RECEPTOR; ULTRAVIOLET B; KERATINOCYTE;

D O I：

10.1016/0014-5793(95)00912-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of ultraviolet B (UVB) irradiation on endothelin-l (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm(2) increased ET-I secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ET(A) and ET(B) receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm(2) UVB irradiation.

引用

页码：188 / 190

页数：3

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