DNA DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION - INVOLVEMENT OF DNA-PK

被引：330

作者：

JACKSON, SP

JEGGO, PA

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE,ENGLAND

[2] UNIV SUSSEX,MRC,CELL MUTAT UNIT,BRIGHTON BN1 9RR,E SUSSEX,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(00)89090-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.

引用

页码：412 / 415

页数：4

共 41 条

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