ASSAY OF PARACETAMOL AND ITS METABOLITES IN URINE, PLASMA AND SALIVA OF CHILDREN WITH CHRONIC LIVER-DISEASE

被引：45

作者：

ALOBAIDY, SS

PO, ALW

MCKIERNAN, PJ

GLASGOW, JFT

MILLERSHIP, J

机构：

[1] QUEENS UNIV BELFAST,SCH PHARM,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

[2] QUEENS UNIV BELFAST,ROYAL BELFAST HOSP SICK CHILDREN,DEPT CHILD HLTH,BELFAST BT12 6BE,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 08期

关键词：

ASSAY; LIVER DISEASE; PARACETAMOL METABOLISM; PHARMACOKINETICS;

D O I：

10.1016/0731-7085(95)01303-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic (HPLC) assay of paracetamol and its metabolites is described. The method for quantifying the metabolism of paracetamol in children with chronic liver disease and the good correlation between plasma and salivary concentrations of paracetamol is demonstrated. Despite an increasing bias between the two methods with increasing concentration of paracetamol, it is concluded that salivary assay is satisfactory for characterising paracetamol pharmacokinetics in the group of patients studied.

引用

页码：1033 / 1039

页数：7

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