REGIOSELECTIVE FORMATION OF A MISONIDAZOLE-GLUTATHIONE CONJUGATE AS A FUNCTION OF PH DURING CHEMICAL-REDUCTION

被引:16
作者
CHACON, E
MORROW, CJ
LEON, AA
BORN, JL
SMITH, BR
机构
[1] UNIV NEW MEXICO,COLL PHARM,ALBUQUERQUE,NM 87131
[2] UNIV NEW MEXICO,DEPT CHEM,ALBUQUERQUE,NM 87131
[3] UNIV NEW MEXICO,DEPT RADIOL,ALBUQUERQUE,NM 87131
关键词
D O I
10.1016/0006-2952(88)90743-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:361 / 363
页数:3
相关论文
共 17 条
[1]  
BORN JL, 1983, J LABELLED COMP RADI, V3, P429
[2]   SELECTIVE RADIOSENSITIZATION OF HYPOXIC CELLS OF MOUSE TUMORS WITH NITROIMIDAZOLES METRONIDAZOLE AND RO 7-0582 [J].
BROWN, JM .
RADIATION RESEARCH, 1975, 64 (03) :633-647
[3]  
CLEMENT JJ, 1980, CANCER RES, V40, P4165
[4]   REACTIONS OF NITROIMIDAZOLES - NUCLEOPHILIC-SUBSTITUTION OF THE NITRO-GROUP [J].
GOLDMAN, P ;
WUEST, JD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (20) :6224-6226
[5]   THE THERAPEUTIC POTENTIAL OF MISONIDAZOLE ENHANCEMENT OF ALKYLATING AGENT CYTO-TOXICITY [J].
HIRST, DG ;
BROWN, JM .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :639-642
[6]   2-HYDROXYLAMINOIMIDAZOLES - UNSTABLE INTERMEDIATES IN THE REDUCTION OF 2-NITROIMIDAZOLES [J].
MCCLELLAND, RA ;
FULLER, JR ;
SEAMAN, NE ;
RAUTH, AM ;
BATTISTELLA, R .
BIOCHEMICAL PHARMACOLOGY, 1984, 33 (02) :303-309
[7]   ELECTROPHILIC INTERMEDIATE IN THE REACTIONS OF A 2-(HYDROXYLAMINO)IMIDAZOLE - A MODEL FOR BIOLOGICAL EFFECTS OF REDUCED NITROIMIDAZOLES [J].
MCCLELLAND, RA ;
PANICUCCI, R ;
RAUTH, AM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (06) :1762-1763
[8]   INTRACELLULAR-LOCALIZATION OF RADIOACTIVELY LABELED MISONIDAZOLE IN EMT-6 TUMOR-CELLS INVITRO [J].
MILLER, GG ;
NGANLEE, J ;
CHAPMAN, JD .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :741-744
[9]   REDUCTIVE FRAGMENTATION OF 2-NITROIMIDAZOLES IN THE PRESENCE OF NITROREDUCTASES - GLYOXAL FORMATION FROM MISONIDAZOLE [J].
RALEIGH, JA ;
LIU, SF .
BIOCHEMICAL PHARMACOLOGY, 1983, 32 (08) :1444-1446
[10]   REDUCTIVE FRAGMENTATION OF 2-NITROIMIDAZOLES - AMINES AND ALDEHYDES [J].
RALEIGH, JA ;
LIU, SF .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (08) :1337-1340