REGIOSELECTIVE FORMATION OF A MISONIDAZOLE-GLUTATHIONE CONJUGATE AS A FUNCTION OF PH DURING CHEMICAL-REDUCTION

被引：16

作者：

CHACON, E

MORROW, CJ

LEON, AA

BORN, JL

SMITH, BR

机构：

[1] UNIV NEW MEXICO,COLL PHARM,ALBUQUERQUE,NM 87131

[2] UNIV NEW MEXICO,DEPT CHEM,ALBUQUERQUE,NM 87131

[3] UNIV NEW MEXICO,DEPT RADIOL,ALBUQUERQUE,NM 87131

来源：

BIOCHEMICAL PHARMACOLOGY | 1988年 / 37卷 / 02期

关键词：

D O I：

10.1016/0006-2952(88)90743-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：361 / 363

页数：3

共 17 条

[1]

BORN JL, 1983, J LABELLED COMP RADI, V3, P429

[2] SELECTIVE RADIOSENSITIZATION OF HYPOXIC CELLS OF MOUSE TUMORS WITH NITROIMIDAZOLES METRONIDAZOLE AND RO 7-0582 [J].

BROWN, JM .

RADIATION RESEARCH, 1975, 64 (03) :633-647

[3]

CLEMENT JJ, 1980, CANCER RES, V40, P4165

[4] REACTIONS OF NITROIMIDAZOLES - NUCLEOPHILIC-SUBSTITUTION OF THE NITRO-GROUP [J].

GOLDMAN, P ;

WUEST, JD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (20) :6224-6226

[5] THE THERAPEUTIC POTENTIAL OF MISONIDAZOLE ENHANCEMENT OF ALKYLATING AGENT CYTO-TOXICITY [J].

HIRST, DG ;

BROWN, JM .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :639-642

[6] 2-HYDROXYLAMINOIMIDAZOLES - UNSTABLE INTERMEDIATES IN THE REDUCTION OF 2-NITROIMIDAZOLES [J].

MCCLELLAND, RA ;

FULLER, JR ;

SEAMAN, NE ;

RAUTH, AM ;

BATTISTELLA, R .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (02) :303-309

[7] ELECTROPHILIC INTERMEDIATE IN THE REACTIONS OF A 2-(HYDROXYLAMINO)IMIDAZOLE - A MODEL FOR BIOLOGICAL EFFECTS OF REDUCED NITROIMIDAZOLES [J].

MCCLELLAND, RA ;

PANICUCCI, R ;

RAUTH, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (06) :1762-1763

[8] INTRACELLULAR-LOCALIZATION OF RADIOACTIVELY LABELED MISONIDAZOLE IN EMT-6 TUMOR-CELLS INVITRO [J].

MILLER, GG ;

NGANLEE, J ;

CHAPMAN, JD .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :741-744

[9] REDUCTIVE FRAGMENTATION OF 2-NITROIMIDAZOLES IN THE PRESENCE OF NITROREDUCTASES - GLYOXAL FORMATION FROM MISONIDAZOLE [J].

RALEIGH, JA ;

LIU, SF .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (08) :1444-1446

[10] REDUCTIVE FRAGMENTATION OF 2-NITROIMIDAZOLES - AMINES AND ALDEHYDES [J].

RALEIGH, JA ;

LIU, SF .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (08) :1337-1340

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