DES-TYROSINE1-GAMMA-ENDORPHIN AND HALOPERIDOL - BEHAVIORAL AND BIOCHEMICAL DIFFERENTIATION

被引：38

作者：

WEINBERGER, SB

ARNSTEN, A

SEGAL, DS

机构：

[1] Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla

来源：

LIFE SCIENCES | 1979年 / 24卷 / 18期

关键词：

D O I：

10.1016/0024-3205(79)90246-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Des-tyrosine -γ-endorphin and haloperidol were found to produce markedly different response profiles in the rat. Behavioral tests used included response to amphetamine and apormorphine challenge, assessment of catalepsy using the vertical grid and horizontal bar, and characterization of exploratory behavior in a multicompartment chamber. In addition, the effect of these agents on caudate synaptosomal dopamine formation was determined. These data are not consistent with the previous report that des-tyrosine -γ-endorphin is a haloperidol-like neuroleptic (6). © 1979.

引用

页码：1637 / 1643

页数：7

共 14 条

[1] ENDORPHINS - PROFOUND BEHAVIORAL-EFFECTS IN RATS SUGGEST NEW ETIOLOGICAL FACTORS IN MENTAL-ILLNESS
BLOOM, F
SEGAL, D
LING, N
GUILLEMIN, R
[J]. SCIENCE, 1976, 194 (4265) : 630 - 632
[2] DETECTION OF NEUROLEPTIC PROPERTIES OF CLOZAPINE, SULPIRIDE AND THIORIDAZINE
COSTALL, B
NAYLOR, RJ
[J]. PSYCHOPHARMACOLOGIA, 1975, 43 (01): : 69 - 74
[3] DEWIED D, 1978, LANCET, V1, P1046
[4] FOG R, 1972, Acta Neurologica Scandinavica Supplementum, V48, P11
[5] Iversen S D, 1977, Adv Biochem Psychopharmacol, V16, P209
[6] INTERACTION OF NEUROLEPTIC AND MUSCARINIC AGENTS WITH CENTRAL DOPAMINERGIC SYSTEMS
KELLY, PH
MILLER, RJ
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1975, 54 (01) : 115 - 121
[7] INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY
KUCZENSKI, R
SEGAL, DS
[J]. JOURNAL OF NEUROCHEMISTRY, 1974, 22 (06) : 1039 - 1044
[8] SEGAL D, 1979, ENDORPHINS MENTAL HL
[9] Segal D S, 1975, Adv Biochem Psychopharmacol, V13, P247
[10] BETA-ENDORPHIN - ENDOGENOUS OPIATE OR NEUROLEPTIC
SEGAL, DS
BROWNE, RG
BLOOM, F
LING, N
GUILLEMIN, R
[J]. SCIENCE, 1977, 198 (4315) : 411 - 413

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