LITHIUM EFFECTS - RELATION TO LITHIUM DOSE AND TO PLASMA PEAK LEVELS

被引:20
作者
MELLERUP, ET [1 ]
DAM, H [1 ]
WILDSCHIODTZ, G [1 ]
RAFAELSEN, OJ [1 ]
机构
[1] RIGSHOSP, INST PSYCHOCHEM, DK-2100 COPENHAGEN, DENMARK
关键词
Lithium dose; lithium effects; plasma lithium peak levels;
D O I
10.1111/j.1600-0447.1979.tb03586.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
In a 24 h study, plasma peak Li was determined in manic-melancholic patients who routinely had their entire Li dose at night. A correlation analysis was undertaken of the relation of plasma peak level and the dose of Li to a number of Li induced changes: increase in urine volume, weight gain, decrease in plasma phosphate, increase in plasma Mg, decrease in plasma urea, increase in plasma alkaline phosphatase, increase in urinary pH. Only the changes in plasma phosphate and in urine pH were significantly correlated to the peak value of plasma Li. The increase in urine volume was significantly correlated to the dose of Li.
引用
收藏
页码:177 / 184
页数:8
相关论文
共 16 条
[1]   LITHIUM MAINTENANCE TREATMENT OF MANIC-MELANCHOLIC PATIENTS - ROLE IN DAILY ROUTINE [J].
BECH, P ;
VENDSBORG, PB ;
RAFAELSEN, OJ .
ACTA PSYCHIATRICA SCANDINAVICA, 1976, 53 (01) :70-81
[2]  
BORG KO, 1974, ACTA PHARM SUEC, V11, P133
[3]  
CHRISTIANSEN C, 1975, Neuropsychobiology, V1, P344, DOI 10.1159/000117511
[4]   COMPARISON OF SIDE-EFFECTS WITH COATED LITHIUM-CARBONATE TABLETS AND LITHIUM-SULFATE PREPARATIONS GIVING MEDIUM-SLOW AND SLOW-RELEASE - DOUBLE-BLIND CROSSOVER STUDY [J].
EDSTROM, A ;
PERSSON, G .
ACTA PSYCHIATRICA SCANDINAVICA, 1977, 55 (02) :153-158
[5]  
FYRO B, 1970, Pharmacologia Clinica, V2, P236, DOI 10.1007/BF00404307
[6]  
MACNEIL S, 1975, LITHIUM RES THERAPY
[7]  
Matussek N, 1971, Nervenarzt, V42, P376
[8]   LITHIUM EFFECTS ON DIURNAL RHYTHM OF CALCIUM, MAGNESIUM, AND PHOSPHATE-METABOLISM IN MANIC-MELANCHOLIC DISORDER [J].
MELLERUP, ET ;
LAURITSEN, B ;
DAM, H ;
RAFAELSEN, OJ .
ACTA PSYCHIATRICA SCANDINAVICA, 1976, 53 (05) :360-370
[9]   LITHIUM EFFECTS ON MAGNESIUM METABOLISM IN RATS [J].
MELLERUP, ET ;
PLENGE, P ;
RAFAELSEN, OJ .
INTERNATIONAL PHARMACOPSYCHIATRY, 1973, 8 (03) :178-183