DIFFERENTIAL-EFFECTS OF PSYCHOTROPIC-DRUGS ON FEEDING IN RATS - IS HISTAMINE BLOCKADE INVOLVED

被引：23

作者：

ORTHENGAMBILL, N

SALOMON, M

机构：

[1] Tufts University, Medford

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 04期

关键词：

Antidepressants; Antihistamines; Antipsychotics; Appetite stimulation; Desipramine; Feeding behavior; Haloperidol; Histamine blockade; Promazine; Rats;

D O I：

10.1016/0091-3057(90)90086-W

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present animal studies tested the hypothesis that drug-induced blockade of histamine-1 receptors leads to appetite stimulation. Test agents included the antipsychotic promazine which has very potent antihistaminic effects, as well as the antipsychotic haloperidol and the antidepressant desipramine which both have negligible antihistaminic effects. In support of the hypothesis, significant appetite stimulation occurred only with promazine, while the other two test agents did not increase feeding, and even produced some suppression in food intake. © 1990.

引用

页码：837 / 841

页数：5

共 21 条

[1] CONCENTRATION OF HISTAMINE IN DIFFERENT PARTS OF BRAIN AND HYPOPHYSIS OF CAT AND ITS MODIFICATION BY DRUGS [J].