FREE-CHOICE ETHANOL INTAKE AND ETHANOL-METABOLISM IN THE HAMSTER AND RAT

被引：53

作者：

KULKOSKY, PJ

CORNELL, NW

机构：

[1] Laboratory of Metabolism, National Institute on Alcohol Abuse and Alcoholism, Rockville

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 04期

关键词：

Alcohol dehydrogenase activity; Ethanol intake; Ethanol metabolism; Ethanol preference; Hamster and rat ethanol intake and preference;

D O I：

10.1016/0091-3057(79)90121-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Hamsters, as previously reported, demonstrated greater ethanol intake and preference than rats. However, as ethanol was gradually added to a sweet solution, hamster ethanol intakes did not consistently exceed ethanol metabolic capacity for prolonged periods. In ethanol-naive hamsters and rats, alcohol dehydrogenase activities and ethanol metabolic rates of isolated hepatocytes in vitro and blood ethanol elimination rates in vivo show consistent large interspecific differences corresponding to the species' differences in ethanol intake and preference. The data suggest a limiting role of ethanol metabolism in the regulation of maximized free-selection ethanol intake by rodents, and provide an explanation for the absence of continuously elevated blood ethanol levels and alcohol withdrawal syndrome in hamsters during periods of comparatively high daily ethanol intake. © 1979.

引用

页码：439 / 444

页数：6

共 52 条

[1] COMPARISON BETWEEN WATER AND ALCOHOL CONSUMPTION IN SIX ANIMAL SPECIES IN FREE-CHOICE EXPERIMENTS [J].