MONITORING OF MITE DERMATOPHAGOIDES-FARINAE ALLERGEN-SPECIFIC IGG AND IGG SUBCLASS DISTRIBUTION IN PATIENTS ON IMMUNOTHERAPY

被引:17
作者
EINARSSON, R
DREBORG, S
HAMMARSTROM, L
LOFKVIST, T
SMITH, CIE
SVENSSON, G
机构
[1] LINKOPING UNIV HOSP,DEPT PEDIAT,S-58185 LINKOPING,SWEDEN
[2] UNIV LUND HOSP,DEPT OTOLARYNGOL,S-22185 LUND,SWEDEN
[3] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN
关键词
DER-F-II; IGG SUBCLASSES; IMMUNOTHERAPY; MITE ALLERGY;
D O I
10.1111/j.1398-9995.1992.tb05092.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
House dust mite D. farinae and Der f II-specific IgG and IgG subclass responses were evaluated in 32 adults with perennial rhinitis undergoing immunotherapy for 1 year by means of IgG-RAST and ELISA. The ELISA method, which is based on subclass-specific monoclonal antibodies could detect 0.5-1.5 ng/ml of specific antibodies. D. farinae and Der f II-specific IgG4 antibodies increased continuously as immunotherapy proceeded, while total IgG and IgG1 antibodies reached a plateau value 6 months after the start of immunotherapy, followed by a slow decrease during maintenance therapy. During the early phase of treatment the concentration of IgG1 and IgG4 antibodies rose, even though the increase of IgG4 antibodies dominated. The positive clinical outcome as measured by the decrease in conjunctival sensitivity was associated with an increased ratio of specific IgG4/IgG1 antibodies as well as the magnitude of the IgG4 subclass response. Quantitation of IgG subclass antibodies in patients undergoing immunotherapy may be of some clinical value, but the clinical usefulness needs to be demonstrated for each type of allergen and possibly also for each assay system.
引用
收藏
页码:76 / 82
页数:7
相关论文
共 34 条
[1]  
AALBERSE RC, 1983, J IMMUNOL, V130, P722
[2]  
AALBERSE RC, 1983, CLIN REV ALLERG, V1, P289
[3]   IMMUNOTHERAPY WITH A STANDARDIZED DERMATOPHAGOIDES-PTERONYSSINUS EXTRACT .1. INVIVO AND INVITRO PARAMETERS AFTER A SHORT COURSE OF TREATMENT [J].
BOUSQUET, J ;
CALVAYRAC, P ;
GUERIN, B ;
HEJJAOUI, A ;
DHIVERT, H ;
HEWITT, B ;
MICHEL, FB .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1985, 76 (05) :734-744
[4]   ANTIBODY-RESPONSE FOLLOWING PROLONGED HYPOSENSITIZATION WITH DERMATOPHAGOIDES-PTERONYSSINUS EXTRACT [J].
CHAPMAN, MD ;
PLATTSMILLS, TAE ;
GABRIEL, M ;
NG, HK ;
ALLAN, WGL ;
HILL, LE ;
NUNN, AJ .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1980, 61 (04) :431-440
[5]  
D'SOUZA M F, 1973, Clinical Allergy, V3, P177, DOI 10.1111/j.1365-2222.1973.tb01320.x
[6]   CHARACTERIZATION OF ALLERGENS IN A CRUDE EXTRACT OF DERMATOPHAGOIDES-FARINAE AND THEIR IDENTIFICATION IN A NEW PURIFIED PREPARATION [J].
DALE, S ;
LANDMARK, E .
ALLERGY, 1984, 39 (08) :572-585
[7]   HIGH IGG4 ANTIBODY LEVEL IS ASSOCIATED WITH FAILURE OF IMMUNOTHERAPY WITH INHALANT ALLERGENS [J].
DJURUP, R ;
MALLING, HJ .
CLINICAL ALLERGY, 1987, 17 (05) :459-468
[8]   THE IGE AND IGG SUBCLASS ANTIBODY-RESPONSE IN PATIENTS ALLERGIC TO YELLOW JACKET VENOM UNDERGOING DIFFERENT REGIMENS OF VENOM IMMUNOTHERAPY [J].
DJURUP, R ;
MALLING, HJ ;
SONDERGAARD, I ;
WEEKE, B .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1985, 76 (01) :46-55
[9]   IGG SUBCLASS ANTIBODY-RESPONSE IN GRASS POLLEN-ALLERGIC PATIENTS UNDERGOING SPECIFIC IMMUNOTHERAPY - PROGNOSTIC VALUE OF SERUM IGG SUBCLASS ANTIBODY-LEVELS EARLY IN IMMUNOTHERAPY [J].
DJURUP, R ;
OSTERBALLE, O .
ALLERGY, 1984, 39 (06) :433-441