IMPAIRMENT BY CYCLOSPORINE-A OF REPERFUSION-INDUCED ARRHYTHMIAS

被引：37

作者：

ARTEAGA, D

ODOR, A

LOPEZ, RM

CONTRERAS, G

PICHARDO, J

GARCIA, E

ARANDA, A

CHAVEZ, E

机构：

[1] INST NACL CARDIOL IGNACIO CHAVEZ,URGENCIAS LAB,MEXICO CITY 014080,DF,MEXICO

[2] INST NACL CARDIOL IGNACIO CHAVEZ,DEPT PATOL,MEXICO CITY 014080,DF,MEXICO

[3] INST NACL NUTR SALVADOR ZUBIRAN,DEPT CIRURGIA EXPTL,MEXICO CITY 014080,DF,MEXICO

来源：

LIFE SCIENCES | 1992年 / 51卷 / 14期

关键词：

D O I：

10.1016/0024-3205(92)90514-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca2+-induced damage of mitochondrial functions.

引用

页码：1127 / 1134

页数：8

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