ISOLATION AND STRUCTURAL ELUCIDATION OF NEW 18-MEMBERED MACROLIDE ANTIBIOTICS, VIRANAMYCIN-A AND VIRANAMYCIN-B

被引：11

作者：

HAYAKAWA, Y

TAKAKU, K

FURIHATA, K

NAGAI, K

SETO, H

机构：

[1] TOKYO INST TECHNOL,FAC BIOSCI & BIOTECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

[2] UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 12期

关键词：

D O I：

10.7164/antibiotics.44.1294

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two cytotoxic antibiotics, designated viranamycins A and B, were isolated from the culture broth of Streptomyces sp. CH41. Their structures were elucidated as new 18-membered macrolides related to virustomycin A and concanamycin A from NMR spectral analysis. Viranamycins A and B inhibited the growth of P388 mouse leukemia and KB human squamous-cell-carcinoma cells.

引用

页码：1294 / 1299

页数：6

共 5 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].