PREVENTION OF POSTMENOPAUSAL BONE LOSS WITH 1-ALPHA-HYDROXY VITAMIN-D3 - A 3-YEAR PROSPECTIVE-STUDY

被引：22

作者：

POUILLES, JM

TREMOLLIERES, F

RIBOT, C

机构：

[1] Service d'Endocrinologie- U.F., Maladies Osseuses et Métaboliques-CHU Purpan, Toulouse Cedex

来源：

CLINICAL RHEUMATOLOGY | 1992年 / 11卷 / 04期

关键词：

OSTEOPOROSIS; PREVENTION; 1-ALPHA-HYDROXY VITAMIN;

D O I：

10.1007/BF02283104

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An open and controlled prospective study was used to assess the preventive efficiency of 1alpha-hydroxy vitamin D3 (1alpha (OH) Vit. D3) on post-menopausal vertebral bone loss. Of the 36 patients included in the study, 25 completed two years of treatment with 1 mug/day of 1alpha (OH) Vit. D3 and 500 mg of calcium. The vertebral bone mineral density measured by dual photon absorptiometry did not vary in the treated group, whereas it decreased significantly in the control group at the end of the 2 years. At two years, withdrawal of treatment led to a significant bone loss, whereas bone mass remained stable in a subgroup of patients who underwent a third year of treatment with 1alpha (OH) Vit. D3. Overall, tolerance was satisfactory. However, urinary calcium increased significantly during treatment and one third of the patients developed hypercalciuria ) 7.5 mmoles/24 h. No variation in either serum calcium or creatinine levels was noted. These results indicate that 1alpha (OH) Vit. D3 could be useful in preventing post-menopausal bone loss provided it was complemented by regular monitoring of urinary calcium excretion.

引用

页码：492 / 497

页数：6

共 33 条

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