SOLUTE DIFFUSION THROUGH DEGRADABLE SEMICRYSTALLINE POLYETHYLENE-GLYCOL POLY(L-LACTIDE) COPOLYMERS

被引:37
作者
LIU, HJ [1 ]
HSIEH, CT [1 ]
HU, DSG [1 ]
机构
[1] NATL TAIWAN INST TECHNOL,DEPT TEXT ENGN,TAIPEI 10672,TAIWAN
关键词
D O I
10.1007/BF00587889
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The diffusion of C.I. direct orange 34(MW = 299) and benzoic acid(MW = 122) through degraded semicrystalline polyethylene glycol(PEG)/poly(L-lactide)(PLLA) block copolymers with various PEG contents and PEG segment lengths at 37-degrees-C was studied by UV-visible spectroscopy, differential scanning calorimetry(DSC), wide angle X-ray diffractometer(WAXS) and scanning electron microscopy(SEM). The influences of the PEG contents, PEG segment lengths and hydrolytic degradation of PEG/PLLA copolymers on the solute diffusion coefficient and mode for transport were investigated. It is concluded that the diffusion rate increases with the increase of PEG contents and PEG segment lengths in PEG/PLLA copolymers. This is understandable that the increase of PEG content and PEG segment length both make the degree of crystallinity decrease. The steady state of mass flux could not be reached at the diffusion times up to 1000 h, because the copolymers underwent hydrolysis reaction during this period. Furthermore, it is understood that the characteristic time of diffusion as defined by the square of film thickness at an instant of time over the diffusion coefficient of solute through polymer decreases with the increasing diffusion time.
引用
收藏
页码:463 / 470
页数:8
相关论文
共 17 条
[1]   BIODEGRADABLE PEO/PLA BLOCK COPOLYMERS [J].
COHN, D ;
YOUNES, H .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1988, 22 (11) :993-1009
[2]  
CRANK J, 1975, MATH DIFFUSION, P52
[3]   BIODEGRADABLE MATERIALS OF POLY(L-LACTIC ACID) .1. MELT-SPUN AND SOLUTION-SPUN FIBERS [J].
ELING, B ;
GOGOLEWSKI, S ;
PENNINGS, AJ .
POLYMER, 1982, 23 (11) :1587-1593
[4]   BIODEGRADABLE POLYMERS FOR USE IN SURGERY - POLYGLYCOLIC-POLY(ACTIC ACID) HOMOPOLYMERS AND COPOLYMERS .1. [J].
GILDING, DK ;
REED, AM .
POLYMER, 1979, 20 (12) :1459-1464
[5]   SOLUTE DIFFUSION IN SWOLLEN MEMBRANES .7. DIFFUSION IN SEMICRYSTALLINE NETWORKS [J].
HARLAND, RS ;
PEPPAS, NA .
COLLOID AND POLYMER SCIENCE, 1989, 267 (03) :218-225
[6]  
HOLLAND S J, 1986, Journal of Controlled Release, V4, P155, DOI 10.1016/0168-3659(86)90001-5
[7]  
HU DSG, 1993, POLYM BULL, V30, P669
[8]   GENERAL CRYSTALLIZATION BEHAVIOR OF POLY(L-LACTIC ACID) [J].
KALB, B ;
PENNINGS, AJ .
POLYMER, 1980, 21 (06) :607-612
[9]   PREPARATION OF BLOCK COPOLY(ESTER ETHER) COMPRISING POLY(L-LACTIDE) AND POLY(OXYPROPYLENE) AND DEGRADATION OF ITS FIBER INVITRO AND INVIVO [J].
KIMURA, Y ;
MATSUZAKI, Y ;
YAMANE, H ;
KITAO, T .
POLYMER, 1989, 30 (07) :1342-1349
[10]   DEGRADATION RATES OF ORAL RESORBABLE IMPLANTS (POLYLACTATES AND POLYGLYCOLATES) - RATE MODIFICATION WITH CHANGES IN PLA-PGA COPOLYMER RATIOS [J].
MILLER, RA ;
BRADY, JM ;
CUTRIGHT, DE .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1977, 11 (05) :711-719