A SIMPLE AND EFFECTIVE ENANTIOMERIC SYNTHESIS OF A CHIRAL PRIMARY AMINE

被引：37

作者：

MIAO, CK ^{[1
]}

SORCEK, R ^{[1
]}

JONES, PJ ^{[1
]}

机构：

[1] BOEHRINGER INGELHEIM PHARMACEUT INC,DEPT ANALYT SCI,RIDGEFIELD,CT 06877

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)77588-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic reduction of chiral 2-(2-pyridyl)-1,3-oxazolidines and 2-pyridyl imines derived from (R)-phenylglycinol and (R)-valinol afforded high diastereomeric selectivity. Upon oxidative cleavage, the S- primary amine with high ee was obtained.

引用

页码：2259 / 2262

页数：4

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