A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PROCEDURE FOR THE SIMULTANEOUS DETERMINATION OF NORFLOXACIN AND FURPROFEN IN RAT PLASMA

被引：12

作者：

CARLUCCI, G ^{[1
]}

MAZZEO, P ^{[1
]}

PALUMBO, G ^{[1
]}

机构：

[1] UNIV LAQUILA,DIPARTIMENTO MED INTERNA & SANITA PUBBL,I-67100 LAQUILA,ITALY

来源：

BIOMEDICAL CHROMATOGRAPHY | 1993年 / 7卷 / 03期

关键词：

D O I：

10.1002/bmc.1130070303

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A rapid and simple high performance liquid chromatographic analytical method is described for the simultaneous determination of norfloxacin and furprofen in rat plasma. Following dichloromethane extraction, the solution was chromatographed in a Vydac anion exchange column using a mobile phase of 0.05 M phosphate buffer (pH=7.0):acetonitrile (80:20, v/v) at a flow-rate of 1.8 mL/min. The drugs were detected by UV absorption at 278 nm. The total chromatographic analysis time was 10 min. The response was linear, 0.1-5.0 mug/mL for norfloxacin and 0.1-3.0 mug/mL for furprofen, respectively. This method is useful for pharmacokinetic studies of these compounds and will facilitate detailed investigations into the interactions between quinolones and furprofen.

引用

页码：126 / 128

页数：3

共 5 条

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