IN-VITRO ACTIVITIES OF OPC-17116, A NEW QUINOLONE - OFLOXACIN - AND SPARFLOXACIN AGAINST CHLAMYDIA-PNEUMONIAE

被引：32

作者：

ROBLIN, PM ^{[1
]}

MONTALBAN, G ^{[1
]}

HAMMERSCHLAG, MR ^{[1
]}

机构：

[1] SUNY HLTH SCI CTR,DEPT PEDIAT,DIV INFECT DIS,BROOKLYN,NY 11203

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 06期

关键词：

D O I：

10.1128/AAC.38.6.1402

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, OPC-17116; ofloxacin; and sparfloxacin were determined. OPC-17116 was slightly less active than sparfloxacin but more active than afloxacin, with a MIC for 90% of strains tested and a minimal chlamydiacidal concentration for 90% of strains tested of 0.5 mu g/ml.

引用

页码：1402 / 1403

页数：2

共 11 条

[1] INFECTION WITH CHLAMYDIA-PNEUMONIAE IN BROOKLYN [J].

CHIRGWIN, K ;

ROBLIN, PM ;

GELLING, M ;

HAMMERSCHLAG, MR ;

SCHACHTER, J .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (04) :757-761

[2] A NEW RESPIRATORY-TRACT PATHOGEN - CHLAMYDIA-PNEUMONIAE STRAIN TWAR [J].

GRAYSTON, JT ;

CAMPBELL, LA ;

KUO, CC ;

MORDHORST, CH ;

SAIKKU, P ;

THOM, DH ;

WANG, SP .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (04) :618-625

[3] INVITRO ACTIVITIES OF 5 QUINOLONES AGAINST CHLAMYDIA-PNEUMONIAE [J].

HAMMERSCHLAG, MR ;

HYMAN, CL ;

ROBLIN, PM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (03) :682-683

[4] PERSISTENT INFECTION WITH CHLAMYDIA-PNEUMONIAE FOLLOWING ACUTE RESPIRATORY ILLNESS [J].

HAMMERSCHLAG, MR ;

CHIRGWIN, K ;

ROBLIN, PM ;

GELLING, M ;

DUMORNAY, W ;

MANDEL, L ;

SMITH, P ;

SCHACHTER, J .

CLINICAL INFECTIOUS DISEASES, 1992, 14 (01) :178-182

[5] INVITRO AND INVIVO ANTIBACTERIAL ACTIVITIES OF A NEW QUINOLONE, OPC-17116 [J].

IMADA, T ;

MIYAZAKI, S ;

NISHIDA, M ;

YAMAGUCHI, K ;

GOTO, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (03) :573-579

[6] SUSCEPTIBILITIES OF MYCOPLASMA-HOMINIS, MYCOPLASMA-PNEUMONIAE, AND UREAPLASMA-UREALYTICUM TO A NEW QUINOLONE, OPC 17116 [J].

KENNY, GE ;

CARTWRIGHT, FD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1726-1727

[7] INVITRO AND INVIVO ANTICHLAMYDIAL ACTIVITIES OF NEWLY DEVELOPED QUINOLONE ANTIMICROBIAL AGENTS [J].

KIMURA, M ;

KISHIMOTO, T ;

NIKI, Y ;

SOEJIMA, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) :801-803

[8] OFLOXACIN TREATMENT OF CHLAMYDIA-PNEUMONIAE (STRAIN TWAR) LOWER RESPIRATORY-TRACT INFECTIONS [J].

LIPSKY, BA ;

TACK, KJ ;

KUO, CC ;

WANG, SP ;

GRAYSTON, JT .

AMERICAN JOURNAL OF MEDICINE, 1990, 89 (06) :722-724

[9] INVITRO SUSCEPTIBILITIES OF MYCOPLASMS AND UREAPLASMAS TO NEW MACROLIDES AND ARYL-FLUOROQUINOLONES [J].

WAITES, KB ;

CASSELL, GH ;

CANUPP, KC ;

FERNANDES, PB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (10) :1500-1502

[10] THE INVITRO ACTIVITY OF OPC-17116, A NEW 5-METHYL SUBSTITUTED QUINOLONE [J].

WISE, R ;

ANDREWS, JM ;

BRENWALD, N .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 31 (04) :497-504

← 1 2 →