REGIONAL VARIATION AND AGE-RELATED-CHANGES OF LYSOSOMAL-ENZYMES IN THE HUMAN RETINAL-PIGMENT EPITHELIUM

被引：57

作者：

BOULTON, M ^{[1
]}

MORIARTY, P ^{[1
]}

JARVISEVANS, J ^{[1
]}

MARCYNIUK, B ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CELL & STRUCT BIOL,MANCHESTER,ENGLAND

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 1994年 / 78卷 / 02期

关键词：

D O I：

10.1136/bjo.78.2.125

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In this study the activities of two lysosomal enzymes in retinal pigment epithelial (RPE) cells isolated from three regions of the human fundus were examined: the macula, the nasal midzone, and the periphery. The results obtained showed that the activities of acid phosphatase and cathepsin D were significantly higher in the RPE cells derived from the macular region when compared with those in the periphery. The values for the midzone appeared to be intermediate between the other two regions. Furthermore, the overall activity of both enzymes increased as a function of age.

引用

页码：125 / 129

页数：5

共 30 条

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