Three-component model of oestrogen formation and regulation of intratumoural oestrogen pool in breast neoplasms

被引：9

作者：

Berstein, LM

Santen, RJ

Santner, SJ

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT INTERNAL MED,DETROIT,MI 48201

[2] NN PETROV ONCOL RES INST,ENDOCRINOL LAB,ST PETERSBURG 189646,RUSSIA

来源：

MEDICAL HYPOTHESES | 1995年 / 45卷 / 06期

关键词：

D O I：

10.1016/0306-9877(95)90243-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Although a two-component model system (i.e. epithelial and stromal spindle-shaped cells) may explain the regulation of aromatase activity and the location of possible intratumoural sources of oestrogen production in mammary neoplasms, a third component, consisting of lymphocytes and macrophages, may also be considered. Examples are presented, suggesting the importance of a three-component model for a more complete understanding of the regulation of oestrogen production in breast-tumour tissue.

引用

页码：588 / 590

页数：3

共 23 条

[1] LYMPHOCYTE INFILTRATES AS A PROGNOSTIC VARIABLE IN FEMALE BREAST-CANCER [J].