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EFFECT OF AMPHOTERICIN-B ON THE LIPIDS OF 5 DIFFERENT STRAINS OF CRYPTOCOCCUS-NEOFORMANS

被引：7
作者：
FRANZOT, SP
HAMDAN, JS
机构：
[1] Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais, 31.270-901, Caixa Postal 486, Belo Horizonte
来源：
MYCOPATHOLOGIA | 1994年 / 128卷 / 02期
关键词：
AMPHOTERICIN B; CRYPTOCOCCUS NEOFORMANS; LIPIDS; STEROLS;
D O I：
10.1007/BF01103014
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cells of five strains of Clyptococcus neoformans were obtained for partial analysis of lipid composition. Quantitative analysis of lipids and sterols were completed, as well as qualitative analysis of sterols by thin-layer chromatography and by the ultraviolet spectra, Such determinations were made on cells cultured in the absence and presence of amphotericin B at sub-MIC (minimal inhibitory concentration) levels. Marked alterations of the lipid and sterol contents were observed in the amphotericin B - treated cells. Moreover, ergosterol disappeared in these antibiotic-exposed cells, It is concluded that amphotericin B altered the lipid profiles, especially sterols of C. neoformans.
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页码：85 / 89
页数：5
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