HAEMODYNAMIC RESPONSES TO EXERCISE IN HYPERTENSION - PLACE OF SYMPATHETIC NERVOUS SYSTEM EVALUATED BY A NEW SELECTIVE CARDIAC BETA-ADRENERGIC BLOCKING AGENT ICI 50,172

Authors' Synopsis: Intravenous administration of a new cardio-selective β-adrenergic blocking agent with intrinsic sympathetic activity, but, unlike propranolol, with no quinidine-like activity, produced insignificant haemodynamic effects at rest. On treadmill exercise, however, blood pressure, heart rate, cardiac output, and left ventricular work were reduced, peripheral resistance remaining unaltered.