INDUCTION OF DNA-REPAIR REPLICATION BY HYDROXYUREA IN HUMAN-LYMPHOBLASTOID CELLS MEDIATED BY LIVER-MICROSOMES AND NADPH

被引：33

作者：

ANDRAE, U

GREIM, H

机构：

[1] Gesellschaft f. Strahlen- und Umweltforschung, Abteilung für Toxikologie, München, Ingolstadter Landstr. 1

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91645-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydroxyurea induces repair replication in human lymphoblastoid NC37 BaEV cells during incubation with liver microsomes and NADPH. Catalase reduces hydroxyurea-induced repair by more than 95%, suggesting that hydrogen peroxide derived from hydroxyurea in the presence of the metabolic activation system is involved in the DNA damage. © 1979.

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页码：50 / 58

页数：9

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