FORMATION OF ALTERED ENZYMES IN AGING ANIMALS

被引：90

作者：

ROTHSTEIN, M

机构：

[1] Division of Cell and Molecular Biology, State University of New York at Buffalo, Buffalo

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1979年 / 9卷 / 3-4期

关键词：

D O I：

10.1016/0047-6374(79)90099-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence is accumulating which supports the idea that the alteration of enzymes is due to post-synthetic modifications rather than to sequence changes. Although unequivocal proof is still lacking, the idea that the changes in old enzymes are due to a subtle denaturation rather than to covalent changes is strengthened by recent work. That altered enzymes may result from a slowed protein turnover in old organisms appears to be a viable hypothesis. © 1979.

引用

收藏

页码：197 / 202

页数：6

相关论文

共 24 条

[1] DECREASE IN SPECIFIC ACTIVITY OF HEART AND MUSCLE ALDOLASE IN OLD MICE [J].

CHETSANGA, CJ ;

LISKIWSKYI, M .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1977, 8 (11) :753-756

[2] INACTIVE ENZYME MOLECULES IN AGING MICE - LIVER ALDOLASE [J].

GERSHON, H ;

GERSHON, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :909-913

[3] DETECTION OF INACTIVE ENZYME MOLECULES IN AGEING ORGANISMS [J].

GERSHON, H ;

GERSHON, D .

NATURE, 1970, 227 (5264) :1214-&

[4]

GERSHON H, 1973, Mechanisms of Ageing and Development, V2, P33, DOI 10.1016/0047-6374(73)90006-7

[5]

GUPTA SK, 1976, ARCH BIOCHEM BIOPHYS, V174, P333, DOI 10.1016/0003-9861(76)90352-0

[6] PHOSPHOGLYCERATE KINASE FROM YOUNG AND OLD TURBATRIX-ACETI [J].

GUPTA, SK ;

ROTHSTEIN, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 445 (03) :632-644

[7]

GURTLER VB, 1970, HELV CHIM ACTA, V53, P654

[8] HUMAN PAROTID ALPHA-AMYLASE - TEST OF ERROR THEORY OF AGING [J].

HELFMAN, PM ;

PRICE, PA .

EXPERIMENTAL GERONTOLOGY, 1974, 9 (5-6) :209-214

[9] EVIDENCE FOR STRUCTURAL DIFFERENCES BETWEEN HUMAN GLUCOSE-6-PHOSPHATE-DEHYDROGENASE PURIFIED FROM LEUKOCYTES AND ERYTHROCYTES [J].

KAHN, A ;

BERTRAND, O ;

COTTREAU, D ;

BOIVIN, P ;

DREYFUS, JC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 77 (01) :65-72

[10] MODIFICATIONS OF PURIFIED GLUCOSE-6-PHOSPHATE-DEHYDROGENASE AND OTHER ENZYMES BY A FACTOR OF LOW-MOLECULAR WEIGHT ABUNDANT IN SOME LEUKEMIC-CELLS [J].

KAHN, A ;

BOIVIN, P ;

RUBINSON, H ;

COTTREAU, D ;

MARIE, J ;

DREYFUS, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) :77-81