REGIONAL DISTRIBUTION OF A HIGH-AFFINITY ENKEPHALIN-DEGRADING PEPTIDASE (ENKEPHALINASE) AND EFFECTS OF LESIONS SUGGEST LOCALIZATION IN THE VICINITY OF OPIATE RECEPTORS IN BRAIN

被引：110

作者：

MALFROY, B

SWERTS, JP

LLORENS, C

SCHWARTZ, JC

机构：

[1] Unité 109 de Neurobiologie, Centre Paul Broca, l'INSERM 2ter, 75014 Paris, rue d'Alśia

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 03期

关键词：

D O I：

10.1016/0304-3940(79)90017-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of a high affinity enkephalin-dipeptidylcarboxypeptidase between regions of mouse brain is markedly heterogenous and parallels that of opiate receptors. Furthermore intrastriatal administration of kainic acid as well as interruption of the nigrostriatal dopaminergic pathway by 6-hydroxydopamine (6-OHDA) lead to similar decreases in this peptidase activity and in the number of opiate receptors. On the contrary, no correlation was found betwen low affinity enkephalin degrading enzymes and opiate receptors. © 1979.

引用

页码：329 / 334

页数：6

共 20 条

[1] AIRES D, 1968, EUROP J PHARMACOL, V3, P217
[2] PRESYNAPTIC LOCALIZATION OF OPIATE RECEPTORS IN VAGAL AND ACCESSORY OPTIC SYSTEMS - AUTORADIOGRAPHIC STUDY
ATWEH, SF
MURRIN, LC
KUHAR, MJ
[J]. NEUROPHARMACOLOGY, 1978, 17 (01) : 65 - 71
[3] EXTREMELY RAPID DEGRADATION OF [H-3] METHIONINE-ENKEPHALIN BY VARIOUS RAT TISSUES INVIVO AND INVITRO
DUPONT, A
CUSAN, L
GARON, M
ALVARADOURBINA, G
LABRIE, F
[J]. LIFE SCIENCES, 1977, 21 (07) : 907 - 914
[4] REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN
GLOWINSKI, J
IVERSEN, LL
[J]. JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) : 655 - +
[5] RADIOIMMUNOASSAY OF METHIONINE-ENKEPHALINS AND LEUCINE-ENKEPHALINS IN REGIONS OF RAT-BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY
GROS, C
PRADELLES, P
ROUGET, C
BEPOLDIN, O
DRAY, F
FOURNIEZALUSKI, MC
ROQUES, BP
POLLARD, H
LLORENSCORTES, C
SCHWARTZ, JC
[J]. JOURNAL OF NEUROCHEMISTRY, 1978, 31 (01) : 29 - 39
[6] INVITRO RELEASE OF LEU-ENKEPHALIN AND MET-ENKEPHALIN FROM CORPUS STRIATUM
HENDERSON, G
HUGHES, J
KOSTERLITZ, HW
[J]. NATURE, 1978, 271 (5646) : 677 - 679
[7] IMMUNOHISTOCHEMICAL ANALYSIS OF PEPTIDE PATHWAYS POSSIBLY RELATED TO PAIN AND ANALGESIA - ENKEPHALIN AND SUBSTANCE-P
HOKFELT, T
LJUNGDAHL, A
TERENIUS, L
ELDE, R
NILSSON, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) : 3081 - 3085
[8] KNIGHT M, 1978, J BIOL CHEM, V253, P3843
[9] OPIATE RECEPTOR-BINDING IN PRIMATE SPINAL-CORD - DISTRIBUTION AND CHANGES AFTER DORSAL ROOT SECTION
LAMOTTE, C
PERT, CB
SNYDER, SH
[J]. BRAIN RESEARCH, 1976, 112 (02) : 407 - 412
[10] HYPERSENSITIVITY TO NORADRENALINE IN CORTEX AFTER CHRONIC MORPHINE - RELEVANCE TO TOLERANCE AND DEPENDENCE
LLORENS, C
MARTRES, MP
BAUDRY, M
SCHWARTZ, JC
[J]. NATURE, 1978, 274 (5671) : 603 - 605

← 1 2 →