APPROACHES TO EDITING, ASSIGNMENT AND INTERPRETATION OF PROTON SPECTRA

被引:22
作者
GADIAN, DG
BATES, TE
WILLIAMS, SR
BELL, JD
AUSTIN, SJ
CONNELLY, A
机构
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,NMR UNIT,LONDON W12 0HS,ENGLAND
[2] INST CHILD HLTH,SUB DEPT ACAD RADIOL,LONDON WC1N 1EH,ENGLAND
关键词
D O I
10.1002/nbm.1940040210
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Clinical H-1 spectroscopy of the brain is complemented by parallel analyses of biopsy specimens and by studies of animal models of disease. H-1 spectroscopy has been carried out on perchloric acid extracts of biopsy specimens from patients with intracranial tumours. The data suggest that clinical spectroscopy may be useful in the identification and grading of these tumours. In addition, the spectra from extracts derived from normal white matter add weight to the possibility that acetyl-containing compounds other than N-acetylaspartate may make a significant contribution to the signal at 2.0 ppm in vivo. Edited H-1 spectra of brain metabolites in rats with acute liver failure demonstrate an elevation of glutamine and of lactate, suggesting a role for H-1 spectroscopy in clinical investigations of metabolic encephalopathies. However, the observation and resolution of signals from glutamate and glutamine is more difficult at the lower fields that are available for clinical spectroscopy. Finally, some studies of patients with inborn errors of metabolism are described. It is shown that in a disorder of oxidative metabolism, brain lactate can be detected without the need for complex spectral editing techniques. Investigations of the metabolic abnormalities associated with Canavan's disease have shed further light on a possible role for N-acetylaspartate.
引用
收藏
页码:85 / 89
页数:5
相关论文
共 17 条
  • [1] AUSTIN SJ, IN PRESS MAGN RESON
  • [2] OBSERVATION OF CEREBRAL METABOLITES IN AN ANIMAL-MODEL OF ACUTE LIVER-FAILURE INVIVO - A H-1 AND P-31 NUCLEAR MAGNETIC-RESONANCE STUDY
    BATES, TE
    WILLIAMS, SR
    KAUPPINEN, RA
    GADIAN, DG
    [J]. JOURNAL OF NEUROCHEMISTRY, 1989, 53 (01) : 102 - 110
  • [3] FINN JP, 1989, 8TH ANN M SOC MAGN R, P722
  • [4] LOCALIZED PROTON NMR-SPECTROSCOPY IN DIFFERENT REGIONS OF THE HUMAN-BRAIN INVIVO - RELAXATION-TIMES AND CONCENTRATIONS OF CEREBRAL METABOLITES
    FRAHM, J
    BRUHN, H
    GYNGELL, ML
    MERBOLDT, KD
    HANICKE, W
    SAUTER, R
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1989, 11 (01) : 47 - 63
  • [5] FRAHM J, 1991, NMR BIOMED, V4
  • [6] NEUROMETABOLIC EFFECTS OF AN INBORN ERROR OF AMINO-ACID-METABOLISM DEMONSTRATED INVIVO BY H-1-NMR
    GADIAN, DG
    PROCTOR, E
    WILLIAMS, SR
    CADY, EB
    GARDINER, RM
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1986, 3 (01) : 150 - 156
  • [7] PROTON MR SPECTROSCOPY OF INTRACRANIAL TUMORS - INVIVO AND INVITRO STUDIES
    GILL, SS
    THOMAS, DGT
    VANBRUGGEN, N
    GADIAN, DG
    PEDEN, CJ
    BELL, JD
    COX, IJ
    MENON, DK
    ILES, RA
    BRYANT, DJ
    COUTTS, GA
    [J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1990, 14 (04) : 497 - 504
  • [8] INVIVO ASSESSMENT OF N-ACETYLASPARTATE IN BRAIN IN SPONGY DEGENERATION (CANAVANS DISEASE) BY PROTON SPECTROSCOPY
    GRODD, W
    KRAGELOHMANN, I
    PETERSEN, D
    TREFZ, FK
    HARZER, K
    [J]. LANCET, 1990, 336 (8712) : 437 - 438
  • [9] SPATIALLY LOCALIZED H-1-NMR SPECTRA OF METABOLITES IN THE HUMAN-BRAIN
    HANSTOCK, CC
    ROTHMAN, DL
    PRICHARD, JW
    JUE, T
    SHULMAN, RG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (06) : 1821 - 1825
  • [10] CEREBRAL ENERGY-METABOLISM AND INTRACELLULAR PH DURING SEVERE HYPOXIA AND RECOVERY - A STUDY USING H-1, P-31 AND H-1[C-13] NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY IN THE GUINEA-PIG CEREBRAL-CORTEX INVITRO
    KAUPPINEN, RA
    WILLIAMS, SR
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1990, 26 (03) : 356 - 369