ASSOCIATION OF IMMUNOGLOBULIN KM AND GM ALLOTYPES WITH SPECIFIC ANTINUCLEAR ANTIBODIES AND DISEASE SUSCEPTIBILITY AMONG CONNECTIVE-TISSUE DISEASE PATIENTS

被引:38
作者
HOFFMAN, RW
SHARP, GC
IRVIN, WS
ANDERSON, SK
HEWETT, JE
PANDEY, JP
机构
[1] HARRY S TRUMAN MEM VET HOSP,MED RES SERV,COLUMBIA,MO 65201
[2] UNIV MISSOURI,DEPT MED,COLUMBIA,MO 65201
[3] UNIV MISSOURI,DEPT PATHOL,COLUMBIA,MO 65201
[4] UNIV MISSOURI,DEPT STAT,COLUMBIA,MO 65201
[5] MED UNIV S CAROLINA,DEPT IMMUNOL & MICROBIOL,CHARLESTON,SC 29425
来源
ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 04期
关键词
D O I
10.1002/art.1780340410
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The distribution of the immunoglobulin Km(1) and Gm phenotypes was examined in patients with connective tissue diseases, including systemic lupus erythematosus, mixed connective tissue disease, and scleroderma, whose sera were characterized for antibodies against nuclear antigens and polypeptides of U small nuclear ribonucleoproteins. We found a strong association between the Km(1) phenotype and susceptibility to systemic lupus erythematosus (P < 0.00001, relative risk = 17). We also found a positive association between the Km(1) phenotype and the presence of anti-double-stranded DNA antibodies. The presence of certain immunoglobulin genes or gene families may have a role in susceptibility to the development of autoantibodies and/or of connective tissue disease.
引用
收藏
页码:453 / 458
页数:6
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