SAPONINS OF THE IVY PLANT, HEDERA-HELIX, AND THEIR LEISHMANICIDIC ACTIVITY

被引：71

作者：

MAJESTERSAVORNIN, B

ELIAS, R

DIAZLANZA, AM

BALANSARD, G

GASQUET, M

DELMAS, F

机构：

[1] FAC PHARM MARSEILLE, PHARMACOGNOSIE LAB, 27 BLVD JEAN MOULIN, F-13385 MARSEILLE 5, FRANCE

[2] FAC PHARM MARSEILLE, PARASITOL LAB, F-13385 MARSEILLE 5, FRANCE

[3] UNIV ALCALA DE HENARES, FAC PHARM, PHARMACOGNOSIE LAB, ALCALA DE HENARES, SPAIN

来源：

PLANTA MEDICA | 1991年 / 57卷 / 03期

关键词：

HEDERA-HELIX L; ARALIACEAE; HEDERASAPONIN; HEDERIN; HEDERAGENIN; LEISHMANICIDIC ACTIVITY; LEISHMANIA-INFANTUM; LEISHMANIA-TROPICA;

D O I：

10.1055/s-2006-960086

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Antileishmanial activity is reported for the first time for saponins of ivy, Hedera helix L., in vitro on promastigote and amastigote forms of Leishmania infantum and Leishmania tropica. The compounds tested were an extract containing 60% of saponic complex (CS 60), the bidesmosides hederasaponin B, C and D (saponin K10), their corresponding monodesmosides alpha-, beta-, and delta-hederin, and hederagenin. CS 60 and bidesmosides have shown no effect. Monodesmosides were found to be as effective on promastigote forms as the reference compound (pentamidine). Against amastigote forms only hederagenin exhibited a significant activity which was equivalent to that of the reference compound (N-methylglucamine antimonate).

引用

页码：260 / 262

页数：3

共 9 条

[1] TWO-DIMENSIONAL NMR-STUDIES OF TRITERPENOID GLYCOSIDES - H-1 AND C-13 NMR ASSIGNMENTS OF HEDERASAPONIN-C [3-O-ALPHA-L-RHAMNOPYRANOSYL-(1-]2)-ALPHA-L-ARABINOPYRANOSYL-HEDERAGENIN 28-O-ALPHA-L-RHAMNOPYRANOSYL-(1-]4)-BETA-D-GLUCOPYRANOSYL-(1-]6)-BETA-D-GLUCOPYRANOSYL ESTER [J].