LACK OF NEUROCHEMICAL EVIDENCE FOR NEUROTOXIC EFFECTS OF REPEATED COCAINE ADMINISTRATION IN RATS ON BRAIN MONOAMINE NEURONS

被引：58

作者：

YEH, SY

DESOUZA, EB

机构：

[1] National Institute On Drug Abuse, Addiction Research Center, Baltimore, MD

来源：

DRUG AND ALCOHOL DEPENDENCE | 1991年 / 27卷 / 01期

关键词：

REPEATED COCAINE ADMINISTRATION; COCAINE; NOREPINEPHRINE; DOPAMINE; DIHYDROXYPHENYLACETIC ACID; HOMOVANILLIC ACID; SEROTONIN; 5-HYDROXYINDOLEACETIC ACID;

D O I：

10.1016/0376-8716(91)90086-E

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Rats were injected with cocaine (20 mg/kg, s.c. or i.p. twice daily for 8 days) or saline and killed at 1, 8, 15 or 48 days after the last injection. The concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and their metabolites, assayed by HPLC-EC, in frontal cortex, hippocampus, striatum, hypothalamus, midbrain, pons-medulla and spinal cord were not significantly different from those in the saline-injected controls at any of the time points examined. These data suggest that the repeated cocaine administration in rats does not produce any long-term depletion in brain catecholamine and 5-HT content suggesting no neurotoxic effects of the drug.

引用

页码：51 / 61

页数：11

共 34 条

[31] CHRONIC COCAINE ADMINISTRATION DECREASES DOPAMINE SYNTHESIS RATE AND INCREASES [H-3] SPIROPERIDOL BINDING IN RAT-BRAIN [J].