PHARMACOKINETICS OF AZITHROMYCIN AFTER SINGLE ORAL DOSING OF EXPERIMENTAL-ANIMALS

被引：30

作者：

DAVILA, D ^{[1
]}

KOLACNYBABIC, L ^{[1
]}

PLAVSIC, F ^{[1
]}

机构：

[1] REBRO CLIN HOSP, DEPT CLIN PHARMACOL, Zagreb, Croatia, YUGOSLAVIA

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1991年 / 12卷 / 07期

关键词：

AZITHROMYCIN; ERYTHROMYCIN; PHARMACOKINETICS; TISSUE LEVELS;

D O I：

10.1002/bdd.2510120704

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Azithromycin, a macrolide antibiotic with an enhanced antimicrobial spectrum, was found to have a longer half-life than erythromycin, with marked tissue penetration. The pharmacokinetics of azithromycin after oral administration were compared with those of erythromycin in rats (200 mg kg-1) and rabbits (80 mg kg-1). Concentrations of azithromycin in liver, lung, kidney, ileum, and brain were higher than serum concentrations. The slow decline in tissue concentrations was evident from the biphasic elimination profile. Thus, advantageous pharmacokinetic properties and the broader antimicrobial spectrum of azithromycin relative to erythromycin appear to further support its therapeutic potential.

引用

页码：505 / 514

页数：10

共 16 条

[1] TISSUE PENETRATION OF ANTIBIOTICS [J].

BERGERON, MG .

CLINICAL BIOCHEMISTRY, 1986, 19 (02) :90-100

[2]

CHAN KH, 1988, ARCH OTOLARYNGOL, V114, P1266

[3]

DAVILA D, 1989, PHARMAS 89, P35

[4]

DAVILA D, 1989, 5TH P CZECH C INF PA, P111

[5] ERYTHROMYCIN SERIES .11. RING EXPANSION F ERYTHROMYCIN-A OXIME BY THE BECKMANN REARRANGEMENT [J].

DJOKIC, S ;

KOBREHEL, G ;

LAZAREVSKI, G ;

LOPOTAR, N ;

TAMBURASEV, Z ;

KAMENAR, B ;

NAGL, A ;

VICKOVIC, I .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1986, (11) :1881-1890

[6]

Djokic S, 1988, J CHEM RES, V152, P1239

[7]

FINEGOLD SM, 1982, DIAGNOSTIC MICROBIOL, P554

[8] CORRELATION OF THE EXTRAVASCULAR PHARMACOKINETICS OF AZITHROMYCIN WITH INVIVO EFFICACY IN MODELS OF LOCALIZED INFECTION [J].

GIRARD, AE ;

GIRARD, D ;

RETSEMA, JA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 :61-71

[9] PHARMACOKINETIC AND INVIVO STUDIES WITH AZITHROMYCIN (CP-62,993), A NEW MACROLIDE WITH AN EXTENDED HALF-LIFE AND EXCELLENT TISSUE DISTRIBUTION [J].

GIRARD, AE ;

GIRARD, D ;

ENGLISH, AR ;

GOOTZ, TD ;

CIMOCHOWSKI, CR ;

FAIELLA, JA ;

HASKELL, SL ;

RETSEMA, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (12) :1948-1954

[10] PENETRATION OF CIPROFLOXACIN INTO GYNECOLOGICAL TISSUES FOLLOWING ORAL AND INTRAVENOUS ADMINISTRATION [J].

GOORMANS, E ;

DALHOFF, A ;

KAZZAZ, B ;

BRANOLTE, J .

CHEMOTHERAPY, 1986, 32 (01) :7-17

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