PROTECTIVE EFFECT OF COENZYME-Q10 ON EXERCISE-INDUCED MUSCULAR INJURY

被引：39

作者：

SHIMOMURA, Y

SUZUKI, M

SUGIYAMA, S

HANAKI, Y

OZAWA, T

机构：

[1] NAGOYA UNIV,FAC MED,DEPT BIOMED CHEM,NAGOYA,AICHI 466,JAPAN

[2] NAGOYA UNIV,FAC MED,DEPT INTERNAL MED,NAGOYA,AICHI 466,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)90931-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of coenzyme Q10 administration on exercise-induced muscular injury was examined in rats. Coenzyme Q10-treated and control rats were exercised by 90 min of downhill treadmill running. A part of the animals in both groups were killed immediately after exercise and the others were 40 h postexercise. After the exercise bout, serum creatine kinase and lactate dehydrogenase activities were elevated in the control rats, but not in the coenzyme Q10-treated rats. These enzyme activities in the latter increased to the similar level of the former 40 h postexercise. The muscle coenzyme Q10 content increased by the coenzyme Q10 treatment. These results suggest that the coenzyme Q10 treatment protected skeletal muscles against injury caused during exercise, but not against damage related with inflammatory processes after exercise. © 1991.

引用

页码：349 / 355

页数：7

共 17 条

[1] CREATINE-KINASE ISOENZYME PROFILES AFTER EXERCISE IN THE RAT - SEX-LINKED DIFFERENCES IN LEAKAGE OF CK-MM
AMELINK, GJ
KAMP, HH
BAR, PR
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1988, 412 (04): : 417 - 421
[2] ARMSTRONG RB, 1990, MED SCI SPORT EXER, V22, P429
[3] ECCENTRIC EXERCISE-INDUCED INJURY TO RAT SKELETAL-MUSCLE
ARMSTRONG, RB
OGILVIE, RW
SCHWANE, JA
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1983, 54 (01) : 80 - 93
[4] ASANUMA K, 1985, SEIBUTSU SHIRYO BUNS, V8, P16
[5] BANAUCH D, 1975, Z KLIN CHEM KLIN BIO, V13, P101
[6] METABOLIC CHANGES FOLLOWING ECCENTRIC EXERCISE IN TRAINED AND UNTRAINED MEN
EVANS, WJ
MEREDITH, CN
CANNON, JG
DINARELLO, CA
FRONTERA, WR
HUGHES, VA
JONES, BH
KNUTTGEN, HG
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1986, 61 (05) : 1864 - 1868
[7] HIROSHIMA O, 1985, Vitamins (Kyoto), V59, P457
[8] FREE-RADICAL CHEMISTRY - RELATIONSHIP TO EXERCISE
JENKINS, RR
[J]. SPORTS MEDICINE, 1988, 5 (03) : 156 - 170
[9] MECHANISM RESPONSIBLE FOR ENDOTOXIN-INDUCED LUNG MICROSOMAL DYSFUNCTION IN RATS
KAMBARA, N
TAKAGI, K
SATAKE, T
SUGIYAMA, S
OZAWA, T
[J]. LUNG, 1983, 161 (06) : 361 - 368
[10] KOBAYASHI M, 1980, J APPL BIOCHEM, V2, P270

← 1 2 →