PATTERNS OF INNERVATION OF VASOACTIVE INTESTINAL POLYPEPTIDE, NEUROPEPTIDE-Y, AND GASTRIN-RELEASING PEPTIDE IMMUNOREACTIVE NERVES IN THE FELINE PANCREAS

被引：31

作者：

DEGIORGIO, R ^{[1
]}

STERNINI, C ^{[1
]}

BRECHA, NC ^{[1
]}

WIDDISON, AL ^{[1
]}

KARANJIA, ND ^{[1
]}

REBER, HA ^{[1
]}

GO, VLW ^{[1
]}

机构：

[1] VET ADM WADSWORTH MED CTR,CTR DIGEST DIS,CTR ULCER RES & EDUC,BLDG 115,ROOM 203,LOS ANGELES,CA 90073

来源：

PANCREAS | 1992年 / 7卷 / 03期

关键词：

GASTRIN-RELEASING PEPTIDE; INTRAPANCREATIC GANGLIA; NEUROPEPTIDE-Y; PANCREATIC INNERVATION; PEPTIDERGIC NERVES; VASOACTIVE INTESTINAL POLYPEPTIDE;

D O I：

10.1097/00006676-199205000-00016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY). and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity for each peptide is localized to varicose nerve fibers distributed throughout the exocrine and endocrine pancreas, with some differences in the density and pattern of fiber distribution. In the acinar and stromal compartments, VIP-IR processes have a higher density than NPY- and GRP-containing fibers, the latter being the least abundant. The vasculature receives a particularly prominent NPY innervation, while GRP- and VIP-IR fibers are found occasionally in association with blood vessels. Around ducts, NPY- and VIP-IR nerves are more numerous than those positive for GRP-IR, which are quite sparse. One of the most interesting findings of the present work is the visualization of all peptide-IRs both in neuronal cell bodies and fibers within the intrapancreatic ganglia. VIP-IR is observed in virtually all ganglion cells, while GRP- and NPY-IRs are seen in a few neuronal cells. VIP and NPY tissue levels are much higher than GRP concentrations in all regions of the pancreas. VIP content in the head and body is greater than in the tail. The morphological relationship of VIP-, NPY-, and GRP-IR fibers with different pancreatic structures is consistent with specific peptidergic neural inputs in the regulation of pancreatic functions.

引用

页码：376 / 384

页数：9

共 45 条

[1]

Ahren B., Taborsky G.J., Porte D., Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion, Diabetologia, 29, pp. 827-836, (1986)

[2]

Holst J.J., Neural regulation of pancreatic exocrine function, The Exocrine Pancreas: Biology, Pathobiology, and Diseases, pp. 287-300, (1986)

[3]

Tiscornia O.M., Dreiling D.A., Yacomotti J., Kurtzbart R., De La Torre A., Farache S., Neural control of the exocrine pancreas: An analysis of the cholinergic, adrenergic, and peptidergic pathways and their positive and negative components. Part 2: Integration of neural and hormonal mechanisms, Mt Sinai J Med, 55, pp. 126-131, (1988)

[4]

Sundler F., Alumets J., Hakanson J., Fahrenkrug J., Schaffal-itzky de Muckadell O. Peptidergic (VIP) nerves in the pancreas, Histochemistry, 55, pp. 173-176, (1978)

[5]

Larsson L.I., Innervation of the pancreas by substance P, enkephalin, vasoactive intestinal polypeptide and gastrin/ CCK immunoreactive nerves, J Histochem Cytochem, 27, pp. 1283-1284, (1979)

[6]

Bishop A.E., Polak J.M., Green I.C., Bryant M.G., Bloom S.R., The location of VIP in the pancreas of man and rat, Diabetologia, 18, pp. 73-78, (1980)

[7]

Larsson L.I., Rehfeld J.F., Peptidergic and adrenergic innervation of pancreatic ganglia, Scand J Gastroenterol, 14, pp. 433-437, (1979)

[8]

Gathei M.A., George S.K., Major J.H., Carlei F., Polak J.M., Bloom S.R., Bombesin-like immunoreactivity in the pancreas of man and other mammalian species, Experientia, 40, pp. 884-886, (1984)

[9]

Yanaihara N., Yanaihara C., Mochizuki T., Iwahara K., Fujita T., IwanagaT. Immunoreactive GRP, Peptides, 2, pp. 185-191, (1981)

[10]

Moghimzadeh E., Ekman R., Hakanson R., Yanaihara N., Sun-Dler F., Neuronal gastrin-releasing peptide in the mammalian gut and pancreas, Neuroscience, 10, pp. 553-563, (1983)

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