UV RESISTANCE OF ESCHERICHIA-COLI K-12 DEFICIENT IN CAMP CRP REGULATION

被引：5

作者：

PUYO, MF ^{[1
]}

CALSOU, P ^{[1
]}

SALLES, B ^{[1
]}

机构：

[1] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,205 ROUTE NARBONNE,F-31400 TOULOUSE,FRANCE

来源：

MUTATION RESEARCH | 1992年 / 282卷 / 04期

关键词：

DNA REPAIR; CAMP; SOS SYSTEM; UV IRRADIATION;

D O I：

10.1016/0165-7992(92)90130-A

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Deletion of genes for adenylate cyclase (DELTA-cya) or cAMP receptor protein (DELTA-crp) in E. coli K-12 confers a phenotype that includes resistance to UV radiation (254 nm). Such mutations lead to UV resistance of uvr+, uvrA, lexA and recA strains which could partly be abolished by the addition of cAMP to DELTA-cya but not to DELTA-crp strain culture medium. This effect was not related to either inducibility of major DNA repair genes or growth rate of the bacteria. Enhanced survival was also observed for UV-irradiated lambda-bacteriophage indicating that a repair mechanism of UV lesions was involved in this phenomenon.

引用

页码：247 / 252

页数：6

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