PALLADIUM-CATALYZED COUPLING REACTIONS OF 2,3-DIHYDROFURAN USING HIGH-PRESSURE CONDITIONS

High pressure dramatically influences the palladium catalyzed reaction of 2,3-dihydrofuran (1) and aryl compounds (2-X). An increased activity of the catalyst even in the absence of phosphine ligands has been observed. Nevertheless, using a large excess of ligands does not inhibit the catalyst, however, the regioselectivity of the products strongly depends on the amount of ligand employed. Last but not least, it was demonstrated for the first time that high pressure can act favorably in enantioselective palladium catalysis compared to normal pressure.