DIADENOSINE PHOSPHATES AND THE PHYSIOLOGICAL CONTROL OF BLOOD-PRESSURE

被引：201

作者：

SCHLUTER, H ^{[1
]}

OFFERS, E ^{[1
]}

BRUGGEMANN, G ^{[1
]}

VANDERGIET, M ^{[1
]}

TEPEL, M ^{[1
]}

NORDHOFF, E ^{[1
]}

KARAS, M ^{[1
]}

SPIEKER, C ^{[1
]}

WITZEL, H ^{[1
]}

ZIDEK, W ^{[1
]}

机构：

[1] UNIV MUNSTER,INST BIOCHEM,MED POLIKLIN,D-48129 MUNSTER,GERMANY

来源：

NATURE | 1994年 / 367卷 / 6459期

关键词：

D O I：

10.1038/367186a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

OUR understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides1, endothelial-derived relaxing factor2 and endothelin3. Unidentified vasopressive agents have been found in platelets4. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10(-9) M; in aortic rings, contractions were elicited at 10(-8) M. Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.

引用

页码：186 / 188

页数：3

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