IN-VITRO BIOTRANSFORMATION OF THIAZOPYR BY RAT-LIVER MICROSOMES - OXIDATIVE CLEAVAGE OF A CARBOXYLIC METHYLESTER BY MONOOXYGENASES

被引：5

作者：

FENG, PCC

SOLSTEN, RT

机构：

[1] The Agricultural Group, Monsanto Co., St Louis, MO

来源：

XENOBIOTICA | 1994年 / 24卷 / 08期

关键词：

D O I：

10.3109/00498259409043273

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Thiazopyr was metabolized by liver microsomes from male Sprague-Dawley rats to a previously unidentified metabolite. 2. The new metabolite was identified by coelution with an authentic standard in hplc and by electrospray lc/ms as the corresponding carboxylic acid. 3. Formation of the carboxylic acid metabolite was inhibited in the presence of mono-oxygenase inhibitors including piperonyl butoxide, 1-aminobenzotriazole, metyrapone and tetcyclacis. 4. Transformation of thiazopyr to its carboxylic acid by rat liver microsomes is mediated by mono-oxygenases and not hydrolases.

引用

页码：729 / 734

页数：6

共 12 条

[1] EXAMPLE OF OXIDATIVE DE-ESTERIFICATION OF AN ISOPROPYL ESTER - ITS ROLE IN METABOLISM OF HERBICIDE FLAMPROPISOPROPYL [J].