THE IMMUNOLOGY OF EXCEPTIONAL INDIVIDUALS - THE LESSON OF CENTENARIANS

被引:404
作者
FRANCESCHI, C [1 ]
MONTI, D [1 ]
SANSONI, P [1 ]
COSSARIZZA, A [1 ]
机构
[1] UNIV PARMA, IST CLIN MED GEN & TERAPIA MED, I-43100 PARMA, ITALY
来源
IMMUNOLOGY TODAY | 1995年 / 16卷 / 01期
关键词
D O I
10.1016/0167-5699(95)80064-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Centenarians are the best example of successful ageing, since they have escaped the major age-associated diseases, and most are in good mental and physical condition. Here, Claudio Franceschi and colleagues discuss how the study of their immune systems reveals that several immune parameters are well conserved, suggesting that a complex remodelling of most immune parameters occurs with age, rather than a unidirectional deterioration.
引用
收藏
页码:12 / 16
页数:5
相关论文
共 36 条
[1]   HOW LONG IS THE HUMAN LIFE-SPAN [J].
BARINAGA, M .
SCIENCE, 1991, 254 (5034) :936-938
[2]  
Cossarizza A, 1990, Am J Med Genet Suppl, V7, P213
[3]   PREFERENTIAL EXPRESSION OF V-BETA-6.7 DOMAIN ON HUMAN PERIPHERAL CD4+ T-CELLS - IMPLICATION FOR POSITIVE SELECTION OF T-CELLS IN MAN [J].
COSSARIZZA, A ;
KAHAN, M ;
ORTOLANI, C ;
FRANCESCHI, C ;
LONDEI, M .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (06) :1571-1574
[4]  
COSSARIZZA A, 1991, BLOOD, V77, P1263
[5]  
COSSARIZZA A, 1992, J IMMUNOL RES-ITALY, V4, P118
[6]  
Cossarizza A., 1993, European Journal of Histochemistry, V37, P26
[7]  
COSSARIZZA A, IN PRESS INT REV IMM
[8]   REPLICATIVE SENESCENCE OF HUMAN FIBROBLAST-LIKE CELLS IN CULTURE [J].
CRISTOFALO, VJ ;
PIGNOLO, RJ .
PHYSIOLOGICAL REVIEWS, 1993, 73 (03) :617-638
[9]  
FABRIS N, 1984, LANCET, V1, P983
[10]   INCREASED CYTOKINE PRODUCTION IN MONONUCLEAR-CELLS OF HEALTHY ELDERLY PEOPLE [J].
FAGIOLO, U ;
COSSARIZZA, A ;
SCALA, E ;
FANALESBELASIO, E ;
ORTOLANI, C ;
COZZI, E ;
MONTI, D ;
FRANCESCHI, C ;
PAGANELLI, R .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (09) :2375-2378