STUDIES ON ULTRASTRUCTURAL DISLOCATIONS IN MITOCHONDRIA .2. ON DISLOCATION INDUCED BY LYOPHILIZATION AND MECHANISM OF UNCOUPLING

被引：10

作者：

JOLLY, W

HARRIS, RA

ASAI, J

LENAZ, G

GREEN, DE

机构：

[1] Institute for Enzyme Research, University of Wisconsin, Madison

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1969年 / 130卷 / 1-2期

关键词：

D O I：

10.1016/0003-9861(69)90025-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lyophilization has been shown to uncouple bovine heart mitochondria; however, well-coupled particles may be derived by sonication of the mitochondria uncoupled in this way. An ultrastructural dislocation has been demonstrated by electron microscopy in the cristael membrane of the lyophilized particles. This dislocation is believed to be the morphological basis of uncoupling in lyophilized mitochondria. A mechanism is proposed whereby coupled submitochondrial particles may be derived by sonic irradiation of uncoupled mitochondria. © 1969.

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页码：191 / &

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