PROBING THE FUNCTIONAL-ROLE OF THREONINE-113 OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE FOR ITS EFFECT ON TURNOVER EFFICIENCY, CATALYSIS, AND BINDING

被引:33
作者
FIERKE, CA
BENKOVIC, SJ
机构
[1] DUKE UNIV, MED CTR, DEPT BIOCHEM, BOX 3711, DURHAM, NC 27710 USA
[2] PENN STATE UNIV, DEPT MED, UNIVERSITY PK, PA 16802 USA
关键词
D O I
10.1021/bi00428a011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:478 / 486
页数:9
相关论文
共 63 条
[1]   CONTRIBUTIONS OF HYDROGEN-BONDS OF THR-157 TO THE THERMODYNAMIC STABILITY OF PHAGE-T4 LYSOZYME [J].
ALBER, T ;
SUN, DP ;
WILSON, K ;
WOZNIAK, JA ;
COOK, SP ;
MATTHEWS, BW .
NATURE, 1987, 330 (6143) :41-46
[2]   EVOLUTION OF ENZYME FUNCTION AND DEVELOPMENT OF CATALYTIC EFFICIENCY [J].
ALBERY, WJ ;
KNOWLES, JR .
BIOCHEMISTRY, 1976, 15 (25) :5631-5640
[3]   ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE - ISOLATION AND CHARACTERIZATION OF 2 ISOZYMES [J].
BACCANARI, DP ;
AVERETT, D ;
BRIGGS, C ;
BURCHALL, J .
BIOCHEMISTRY, 1977, 16 (16) :3566-3572
[4]   ANALYSIS OF NUMERICAL-METHODS FOR COMPUTER-SIMULATION OF KINETIC PROCESSES - DEVELOPMENT OF KINSIM - A FLEXIBLE, PORTABLE SYSTEM [J].
BARSHOP, BA ;
WRENN, RF ;
FRIEDEN, C .
ANALYTICAL BIOCHEMISTRY, 1983, 130 (01) :134-145
[5]   INSIGHTS INTO ENZYME FUNCTION FROM STUDIES ON MUTANTS OF DIHYDROFOLATE-REDUCTASE [J].
BENKOVIC, SJ ;
FIERKE, CA ;
NAYLOR, AM .
SCIENCE, 1988, 239 (4844) :1105-1110
[6]   BINDING OF COENZYME ANALOGS TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - BINARY AND TERNARY COMPLEXES [J].
BIRDSALL, B ;
BURGEN, ASV ;
ROBERTS, GCK .
BIOCHEMISTRY, 1980, 19 (16) :3723-3731
[7]   CRYSTALLINE DIHYDROPTEROYLGLUTAMIC ACID [J].
BLAKLEY, RL .
NATURE, 1960, 188 (4746) :231-232
[8]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[9]   PTERIDINE STUDIES .14. METHYLATION OF 2-AMINO-4-HYDROXYPTERIDINE AND RELTED COMPOUNDS [J].
BROWN, DJ ;
JACOBSEN, NW .
JOURNAL OF THE CHEMICAL SOCIETY, 1961, (OCT) :4413-&
[10]   KINETICS OF SUBSTRATE, COENZYME, AND INHIBITOR BINDING TO ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].
CAYLEY, PJ ;
DUNN, SMJ ;
KING, RW .
BIOCHEMISTRY, 1981, 20 (04) :874-879