THE ROLE OF THE MESOLIMBIC DOPAMINERGIC SYSTEM IN THE DESIPRAMINE EFFECT IN THE FORCED SWIMMING TEST

被引：42

作者：

CERVO, L ^{[1
]}

GRIGNASCHI, G ^{[1
]}

SAMANIN, R ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 01期

关键词：

(-) Sulpiride; (Rat); Desipramine; Fluphenazine; Forced swimming test; Nucleus accumbens;

D O I：

10.1016/0014-2999(90)94805-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of sulpiride isomers injected into the nucleus accumbens on the anti-immobility activity of desipramine in rats were studied to clarify the role of dopamine receptors. (-)-Sulpiride 100 ng/0.5 μ1 injected bilaterally into the nucleus accumbens 5 min before testing reduced the effect of a 7-day treatment with 10 mg/kg per day desipramine in the swimming test but 5 μg/0.5 μl (+)-sulpiride injected in the same area had no effect. Fluphenazine, 5 μg/0.5 μl, or 6-hydroxydopamine-induced depletion of dopamine in the nucleus accumbens also reduced the anti-immobility effect of desipramine. The data further support the hypothesis that dopamine transmission in the nucleus accumbens has a permissive role in the effect of desipramine in the forced swimming test. © 1990.

引用

页码：129 / 133

页数：5

共 10 条

[1] STIMULATION OF DOPAMINE D-2 BUT NOT D-1 RECEPTORS REDUCES IMMOBILITY TIME OF RATS IN THE FORCED SWIMMING TEST - IMPLICATION FOR ANTIDEPRESSANT ACTIVITY [J].

BORSINI, F ;

LECCI, A ;

MANCINELLI, A ;

DARANNO, V ;

MELI, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 148 (03) :301-307

[2] EVIDENCE THAT DOPAMINE MECHANISMS IN THE NUCLEUS-ACCUMBENS ARE SELECTIVELY INVOLVED IN THE EFFECT OF DESIPRAMINE IN THE FORCED SWIMMING TEST [J].

CERVO, L ;

SAMANIN, R .

NEUROPHARMACOLOGY, 1987, 26 (10) :1469-1472

[3] REPEATED TREATMENT WITH IMIPRAMINE AND AMITRIPTYLINE REDUCED THE IMMOBILITY OF RATS IN THE SWIMMING TEST BY ENHANCING DOPAMINE MECHANISMS IN THE NUCLEUS ACCUMBENS [J].

CERVO, L ;

SAMANIN, R .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (02) :155-156

[4] 3(H)-SULPIRIDE LABELS MESOLIMBIC NON-DOPAMINERGIC SITES THAT BIND ANTIDEPRESSANT DRUGS [J].

CSERNANSKY, JG ;

CSERNANSKY, CA ;

HOLLISTER, LE .

EXPERIENTIA, 1985, 41 (11) :1419-1421

[5] REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN [J].

GLOWINSKI, J ;

IVERSEN, LL .

JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) :655-+

[6]

JENNER P, 1981, NEUROPHARMACOLOGY, V20, P1285

[7] LIQUID-CHROMATOGRAPHIC ANALYSIS OF CATECHOLAMINES ROUTINE ASSAY FOR REGIONAL BRAIN MAPPING [J].

KELLER, R ;

OKE, A ;

MEFFORD, I ;

ADAMS, RN .

LIFE SCIENCES, 1976, 19 (07) :995-1003

[8]

Konig JFR, 1963, RAT BRAIN STEREOTAXI

[9]

SPANO PF, 1979, SULPIRIDE OTHER BENZ, P11

[10] BEHAVIORAL EVIDENCE FOR SUPER-SENSITIVITY OF POSTSYNAPTIC DOPAMINE-RECEPTORS IN THE MESOLIMBIC SYSTEM AFTER CHRONIC ADMINISTRATION OF DESIPRAMINE [J].

SPYRAKI, C ;

FIBIGER, HC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 74 (2-3) :195-206

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