HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION OF FIBROBLASTS OF DENTAL-PULP IN SEROPOSITIVE PATIENTS

被引：27

作者：

GLICK, M

TROPE, M

BAGASRA, O

PLISKIN, ME

机构：

[1] TEMPLE UNIV, HLTH SCI CTR, SCH MED, DEPT PEDIAT, PHILADELPHIA, PA 19140 USA

[2] TEMPLE UNIV, HLTH SCI CTR, SCH MED, FEHS INST CANC RES & MOLEC BIOL, PHILADELPHIA, PA 19140 USA

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 1991年 / 71卷 / 06期

关键词：

D O I：

10.1016/0030-4220(91)90284-J

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblasts as a possible reservoir for HIV in the body.

引用

页码：733 / 736

页数：4

共 15 条

[1]

BAGASRA O, 1990, MOL ANDROL, V2, P109

[2] BIOLOGIC FEATURES OF HIV-1 THAT CORRELATE WITH VIRULENCE IN THE HOST [J].