INTERLEUKIN-8 INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE IN RAT PERITONEAL NEUTROPHILS

被引：56

作者：

MCCALL, TB

PALMER, RMJ

MONCADA, S

机构：

[1] Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, Langley Court

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90800-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of interleukin(IL)-8 and leukotriene B4 (LTB4) on the induction of nitric oxide (NO) synthase in rat peritoneal neutrophils (PMN) ex vivo was studied. IL-8, but not LTB4, caused concentration-dependent inhibition of the induction of a Ca2+-independent NO synthase ex vivo. The effect of IL-8 was not attributable to the synthesis of an inhibitor of this enzyme. These findings suggest complex regulatory control of the induction of NO synthase by cytokines. © 1992.

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页码：680 / 685

页数：6

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