ONTOGENY OF ABSENCE-LIKE AND TONIC SEIZURES IN THE SPONTANEOUSLY EPILEPTIC RAT

被引：15

作者：

SERIKAWA, T ^{[1
]}

YAMADA, J ^{[1
]}

UJIHARA, H ^{[1
]}

OHNO, Y ^{[1
]}

SASA, M ^{[1
]}

TAKAORI, S ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN

来源：

LABORATORY ANIMALS | 1991年 / 25卷 / 03期

关键词：

SPONTANEOUSLY EPILEPTIC RAT; ABSENCE LIKE SEIZURE; TONIC SEIZURE; TREMOR; STAGGERING GAIT; WEIGHT GAIN;

D O I：

10.1258/002367791780808293

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The ontogeny of epileptic seizures in spontaneously epileptic rats (SER; zi/zi, tm/tm) was studied by examining behaviour and electro-encephalogram (EEG) simultaneously. Weight gain and survival time were also studied. Compared with the control Kyo:Wistar rats, SER showed a much smaller increase in body weight. All male and female SER died before 20 and 18 weeks of age, respectively. Body tremor was observed at 2 weeks of age but disappeared after 11 weeks. Staggering gait appeared after 7 weeks of age, and intensified with age. Absence-like seizures characterized by paroxysmal appearance of 5-7 Hz spike-wave-like complexes were observed in the cortical or hippocampal EEG after 5 weeks of age, and tonic seizures with low voltage fast waves were observed after 6 weeks of age. All SER exhibited both absence-like and tonic seizures with high frequencies from 12 weeks of age. Differences with other spontaneous rat models of epilepsy and application methods for estimating seizure-inhibitory effects of antiepileptic drugs are discussed.

引用

页码：216 / 221

页数：6

共 16 条

[1] BEHAVIORAL-CHARACTERISTICS OF WILD JUMPING OR RUNNING EPISODES IN THE DOUBLE MUTANT SPONTANEOUSLY EPILEPTIC RAT [J].